Table 1 Electrolyte ADR odds ratios and 95% CIs of individual PPIs used as “monotherapy” (Rabeprazole n = 724, Lansoprazole n = 3,360, Pantoprazole n = 3,651, Esomeprazole n = 27,053, Omeprazole n = 7,749) when compared to all H2RAs (n = 8,309).
ADR | PPIs | OR | 95% CI lower | 95% CI upper |
|---|---|---|---|---|
Hypomagnesemia | Omeprazole | 224.6 | 31.0 | 1600.0 |
Esomeprazole | 30.2 | 4.2 | 220.0 | |
Pantoprazole | 115.4 | 16.0 | 840.0 | |
Lansoprazole | 82.4 | 11.0 | 600.0 | |
Rabeprazole | 151.9 | 20.0 | 1200.0 | |
Hypocalcemia | Omeprazole | 75.3 | 19.0 | 300.0 |
Esomeprazole | 10.0 | 2.4 | 41.0 | |
Pantoprazole | 21.7 | 5.1 | 93.0 | |
Lansoprazole | 41.2 | 9.9 | 170.0 | |
Rabeprazole | 28.9 | 5.6 | 150.0 | |
Hypokalemia | Omeprazole | 15.8 | 6.3 | 39.0 |
Esomeprazole | 3.1 | 1.2 | 7.7 | |
Pantoprazole | 6.4 | 2.3 | 18.0 | |
Lansoprazole | 11.0 | 4.1 | 29.0 | |
Rabeprazole | 2.3 | 0.3 | 20.0 | |
Hyponatremia | Omeprazole | 7.0 | 3.3 | 15.0 |
Esomeprazole | 0.6 | 0.3 | 1.4 | |
Pantoprazole | 2.0 | 0.7 | 5.5 | |
Lansoprazole | 4.0 | 1.7 | 9.7 | |
Rabeprazole | 4.3 | 1.1 | 16.0 |
