Table 3 Profiles of ethambutol and streptomycin resistance identified by phenotypic and molecular assays.

S

WT

—

48 (27.3)

R

WT

WT

6 (3.4)*

R

WT

embB M306I (ATG/ATA)

1 (0.6)*

R

WT

embB Y319S

1 (0.6)*

R

WT

embB D328Y, Y334H

1 (0.6)*

R

WT

embB S347T, E504D

1 (0.6)*

R

WT

embB D354A

3 (1.7)*

R

WT

embB L355L, E378A, A505V

6 (3.4)*

R

WT

embB C361Y

1 (0.6)*

R

WT

embB N399T

1 (0.6)*

R

WT

embB G406A

1 (0.6)*

R

WT

embB Q497R, S565G

1 (0.6)*

R

WT

embB D534D

1 (0.6)*

R

embB M306V M1

—

36 (20.5)

S

embB M306V M1

embB M306V

2 (1.1)*

R

embB M306L M2

—

5 (2.8)

R

embB M306I M3

—

15 (8.5)

R

embB M306I M4

—

2 (1.1)

S

embB M306I M4

embB M306I (ATG/ATT)

1 (0.6)*

R

embB M306I M5

—

6 (3.4)

S

embB M306I M5

embB M306I (ATG/ATA)

3 (1.7)*

R

embB Y319C M1

—

1 (0.6)

S

embB Y319C M1

embB Y319C

1 (0.6)*

R

embB G406S M1

—

1 (0.6)

S

embB G406S M1

embB G406S

1 (0.6)*

R

embB G406A M2

—

1 (0.6)

S

embB G406A M2

embB G406A

1 (0.6)*

R

embB G406D M3

—

1 (0.6)

R

embB Q497R M1

—

6 (3.4)

R

embB Q497P M2

—

14 (8.0)

S

embB Q497P M2

embB Q497P

1 (0.6)*

R

embB Q497K M3

—

3 (1.7)

R

embB M306I M3, Q497K M3

—

1 (0.6)

R

embB M306I M5, G406D M3

—

1 (0.6)

R

embB M306I M5, Q497R M1

—

1 (0.6)

S

WT

—

77 (43.8)

R

WT

WT

28 (18.8)*

R

WT

rpsL K88R

5 (2.8)*

R

rpsL K43R M1

rpsL K43R

46 (26.0)

S

rpsL K43R M1

rpsL K43R

2 (1.1)*

—

rpsL K88Q M1

—

0

R

rpsL K88R M2

—

4 (2.3)

R

rrs A513 C M1

—

10 (5.7)

S

rrs A513C M1

rrs A513C

1 (0.6)*

R

rrs A513T M2

—

1 (0.6)

R

rrs C516T M1

—

1 (0.6)

S

rrs C516T M1

rrs C516T

2 (1.1)*