Figure 5

Relationships among the cytotoxic activity of T cells in peripheral blood, normal lung tissues, and tumor tissues. (A) The cytotoxic activity of T cells in PBMC was analyzed for its relationship with that in normal lung-infiltrated cells (NIC) and lung tumor-infiltrated cells (TIC) (n = 27). Each dot represents one patient. Data were combined from triplicate experiments. Correlations between paired data were analyzed using Pearson’s correlation coefficient. (B) The relationship between the phenotype of peripheral T cells and T cell cytotoxicity in lung tumor tissue. The ratio of naïve (CD27⁺ and CD45RA⁺), central memory (TCM, CD27⁺/CD45RA⁻), effector memory (TEM, CD27⁻/CD45RA⁻), and effector memory re-expresses CD45RA (TEMRA, CD45RA⁺/CD27⁻) in CD4⁺ and CD8⁺ T cells was analyzed for correlations with the cytotoxic activity of T cells in lung tumor tissue. Correlations between paired data were analyzed using Pearson’s correlation coefficient.