Figure 1
From: Global Implications of Local Unfolding Phenomena, Probed by Cysteine Reactivity in Human Frataxin
(A) Ribbon representation of the structure of human Frataxin (PDB 1EKG). The C-terminal region (CTR) is shown in red and the side-chains of mutated residues are depicted in sticks (L198, L200, L203 and V134 in yellow, magenta, green and blue, respectively). (B) Local unfolding of the C-terminal region. Under our working hypothesis, the open and closed conformations coexist as native substates.
