Table 1 Qualitative result summary of the optic and electronic microscopy analysis.
3 hours | 3 days | 7 days | |
|---|---|---|---|
Lobular architecture preservation | +++ | ++ | + |
Hepatic plates organization | +++ | ++ | +/− |
Lesions | |||
Hemorrhage | +++ | + | − |
Inflammation | − | + | ++ |
Sinusoidal endothelium | − | − | −/+ |
Hepatocytes | |||
Plasma membrane disruption (EM) | +++ | +++ | +++ |
Plasma membrane disruption (OM) | + | ++ | +++ |
Cellular discohesion (OM) | + | ++ | +++ |
Nuclear changes (OM) | + | ++ | +++ |
Nuclear envelope preservation (EM) | +++ | + | − |
Vessel endothelium | − | +/− | ++ |
Bile duct epithelium | − | ++ | +++ |
Necrosis signs | + | ++ | +++ |
Regeneration Signs | |||
Spindle cells | − | ++ | +++ |
Mitotic stromal cells | − | + | +++ |
Multinucleated hepatocytes | − | ++ | +++ |
Fibrosis | − | + | +++ |
Angiogenesis | − | + | +++ |
Regenerative nodules | − | + | +++ |
Hepatic acinar organization | − | + | ++ |
Neoformation of portal bile ducts | − | ++ | +++ |
Mitotic bile duct epithelium | − | + | +++ |
