Figure 4
ESC1 is an ortholog of Piezo proteins. (a) Schematic diagram of predicted transmembrane topology of ESC1 (At2g48060). Transmembrane domains are indicated by grey boxes. The black dot indicates the premature stop codon in esc1-1. (b) Phylogenetic tree of ESC1/AtPiezo and 17 orthologs in animals and plants. ESC1/AtPiezo (At2g48060) is highlighted by underlining. Homo sapiens (Hs), Mus musculus (Mm), Drosophila melanogaster (Dm), Caenorhabditis elegans (Ce), Ostreococcus lucimarinus (Olu), Selaginella moellendorffii (Sm), Zea mays (Zm), Sorghum bicolor (Sb), Oryza sativa (Os), Brachypodium distachyon (Bd), Solanum lycopersicum (Sl), Vitis vinifera (Vv), Medicago truncatula (Mt), Glycine max (Gm), Cucumis sativus (Csa), Ricinus communis (Ric), Populus trichocarpa (Pt). (c) C-terminus alignments of AtPiezo and its orthologs of C. sativus, G. max, O. sativa and M. musculus. The highly conserved amino acids among Piezo orthologs and the mutation site of esc1-1 are indicated by arrowheads. Anchor domain, Outer Helix, Cap domain, Inner helix and CTD domain are indicated on the above.
