Figure 7 | Scientific Reports

Figure 7

From: High-resolution atmospheric-pressure MALDI mass spectrometry imaging workflow for lipidomic analysis of late fetal mouse lungs

Figure 7

Differential abundance of lipid species in wild type (WT) and Pex11β knockout (KO) late fetal E19 mouse lung tissue sections in negative- and positive-ion mode. Downregulation of [PG(34:1) − H]− lipid (m/z 747.51815), upregulation of [SHexCer(t33:1) + K]+ lipid (m/z 820.46415) in Pex11β KO E19 mouse lungs in negative- and positive-ion mode. The abundance comparisons between lipids in different cryosections were verified by applying various normalization algorithms: (i) no normalization, (ii) total ion count (TIC) normalization, (iii) normalization to homogenously distributed matrix signals and (iv) normalization to homogenously distributed endogenous signals. Scale bar 500 µm.

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