Figure 4
From: Enriched environment alleviates stress-induced dry-eye through the BDNF axis
Bdnf isoforms 1 and 2 modulate basal tear secretion. (a) Model of BdnfSTOP/STOP mice (Homo). (b) Bdnf expression in the hippocampus (HC), hypothalamus (HT), and lacrimal gland (LG). BdnfSTOP/STOP mice showed no expression of exons 1 and 2 in the brain (n = 4–5; **P < 0.01, *P < 0.05, Student’s t-test). (c) Basal tear secretion of BdnfSTOP/STOP mice significantly decreased compared to control mice (n = 6–8; **P < 0.01, Student’s t-test). (d) LG weight was not changed in BdnfSTOP/STOP mice (n = 6–7).
