Table 5 Association between medium-term grade ≥1 cutaneous toxicity and clinical and dosimetric characteristics.
Medium-term grade ≥1 cutaneous toxicity | Univariate analysis* | Multivariate analysis** | ||||
|---|---|---|---|---|---|---|
N | n | % | p-value | HR (95%CI) | p-value | |
Age (years) | — | — | — | 0.51 | NA | |
BMI (kg/m²) | — | — | — | 0.43 | NA | |
Bra cup size (n = 113) | 0.67 | NA | ||||
A-B | 53 | 12 | 22.6% | |||
≥C | 60 | 16 | 26.7% | |||
Smoking | 0.81 | NA | ||||
No | 86 | 21 | 24.4% | |||
Yes | 35 | 10 | 28.6% | |||
Diabetes (n = 119) | 0.20 | NA | ||||
No | 108 | 30 | 27.8% | |||
Yes | 11 | 1 | 9.1% | |||
Chemotherapy | 0.11 | NA | ||||
No | 28 | 4 | 14.3% | |||
Yes | 93 | 27 | 29.0% | |||
Aesthetic aspect before RT (n = 66) | 0.36 | NA | ||||
Moderate | 14 | 1 | 7.1% | |||
Good | 33 | 9 | 27.3% | |||
Excellent | 19 | 5 | 26.3% | |||
Dosimetric parameters | ||||||
Volume of subclavian skin (cc) | — | — | — | 0.052 | 1.02 (1.001–1.05) | 0.049 |
D2% for subclavian PTV (Gy) | — | — | — | 0.084 | 1.13 (0.67–1.89)*** | 0.65 |
D2% for susclavian PTV (Gy) | — | — | — | 0.019 | 0.78 (0.58–1.04)*** | 0.10 |
D50% for breast CTV (Gy) | — | — | — | 0.047 | 0.96 (0.64–1.46)*** | 0.86 |
