Figure 2
From: Lack of IL-17 Receptor A signaling aggravates lymphoproliferation in C57BL/6 lpr mice
Expansion of T cell populations in IL-17RA KO/lpr mice. (A) Total numbers of splenic T cells (CD3+) in wildtype and lpr mice. Bars depict wild type B6 (grey stripe), wild type IL-17RA KO (open stripe), B6/lpr (black), and IL-17RA.KO/lpr (open) mice at 10, 20 and 30 weeks of age. (B) Total numbers of splenic CD4+ T cells (CD3+ CD4+ CD8−) (left) and IL-17A producing CD4+ cells(right) in B6/lpr (black bars) and IL-17RA KO/lpr (open bars). (C) Double negative (DN) splenic T cells (CD3+ CD4− CD8−) (left), and IL-17A producing DN T cells (right) in B6/lpr (black bars) and IL-17RA KO/lpr (open bars) mice at different ages. (D) Double negative (DN) splenic TCRβ+ (DN TCRb+) T cells (CD3+ CD4− CD8− TCRβ+) (left), and IL-17A producing DN TCRβ+ (IL-17A in DN TCRb+) T cells (right) for wild type and lpr mice at week 20 and 30. Mean is shown for n = 9–21 animals per group; *p < 0.05; **p < 0.01.
