Figure 6 | Scientific Reports

Figure 6

From: A novel benzamine lead compound of histone deacetylase inhibitor ZINC24469384 can suppresses HepG2 cells proliferation by upregulating NR1H4

Figure 6

The DEGs and DASGs induced by ZINC24469384 were functionally cross-talked. (A) A merged network include DEGs and DASGs were build based on p53 signaling pathway, JAK/STAT pathway and apoptosis. (B) The mRNA expression of CDKN1A, CDC25A, NR1H4, GADD45α, SOCS1 and SOCS2 in HepG2 cells after ZINC24469384 treated for 4 h, 16 h and 24 h in HepG2 cells. The values calculated three independent experiments and show as mean ± SD. (C) The expression of Cleaved Caspase 9, Cleaved Caspase 3, NR1H4 and p-STAT3 in HepG2 cells using Western Blot after ZINC24469384 treated for 4 h, 16 h and 24 h in HepG2 cells. GAPDH and STAT3 were used as loading control. The values calculated three independent experiments and show as mean ± SD.

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