Table 2 Specific mutations found in ATM gene with concomitant “trunk” mutations (affecting TP53, KRAS, NRAS, BRAF and APC) with relative heterogeneity score.

From: Prognostic impact of ATM mutations in patients with metastatic colorectal cancer

ID	MSI status	ATM		TP53		KRAS		NRAS		BRAF		APC
ID	MSI status	Mutation	HS	Mutation	HS	Mutation	HS	Mutation	HS	Mutation	HS	Mutation	HS
1	MSI	K610T	60	R248Q	70	G12V	70	—	—	—	—	E1464VfsTer8	44
2	NA	E1325Stop	94	R175C	180	—	—	—	—	—	—	—	—
3	MSS	D2870H	52	—	—	G12S	114	—	—	—	—	R1450Stop	106
4	MSS	R3047Stop	88	—	—	G12D	58	—	—	—	—	R1450Stop	46
5	MSI	R337C	32	—	—	G13D	36	—	—	—	—	I1307K	156
6	MSS	P3050L	254	P278S	173	Q61H	120	—	—	—	—	—	—
7	MSI	P604S	132	R196Stop	194	G12V	140	—	—	—	—	E1286Stop	198
8	MSS	R337C	30	I254S	200	G12V	140	—	—	—	—	R1450Stop	64
9	MSS	A1309T	136	S215R	192	—	—	—	—	—	—	S1346Stop	72
10	MSS	V410A	230	—	—	—	—	—	—	—	—	—	—
11	MSS	R337H	34	—	—	—	—	—	—	—		I1311MfsTer10	200
12	NA	R2443Q	184	R273C	290	—	—	—	—	—	—	E1353FfsTer20	284
13	MSS	R337C	114	—	—	A146T	212	—	—	—	—	T1438HfsTer35	106
14	MSS	E1704D	240	—	—	—	—	—	—	—	—	E1379Stop	710
15	MSS	Q2729H	128	—	—	A146T	104	—	—	—	—	T1556NfsTer3	76
16	MSS	V410A	200	—	—	—	—	—	—	—	—	E1309DfsTer4	158
17	MSS	R337H	46	R249G	42	G12V	46	—	—	—	—	—	—
18	MSS	P604S	194	R273H	306	—	—	—	—	—	—	Q12894Stop	320
19	MSS	R2691H	52	C238Y	122	—	—	—	—	—	—	E1317Q	158
20	MSS	R337C	50	—	—	G12V	96	—	—	—	—	H1349QfsTer4	166
21	MSS	S333F	40	G266E	760	—	—	—	—	—	—	—	—
22	MSS	L1939V	44	R282W	268	—	—	—	—	—	—	—	—
23	MSS	V410A	142	I251S	98	—	—	—	—	—	—	E1547Stop	86
24	MSS	V410A	314	Y205H	207	—	—	—	—	—	—	—	—
25	MSS	R337H	108	R175H	196	G13D	190	—	—	—	—	—	—
26	MSS	S333F	290	R273C	140	—	—	—	—	—	—	—	—
27	MSS	S1691R	204	R175H	113	—	—	—	—	—	—	—	—
28	MSS	splice site 184_185 + K1992T	212 + 102	V73fs*50	90	—	—	—	—	V600E	350	—	—
29	MSI	F1928fs*9	206	R27H + R17H	340	—	—	—	—	V600E	468	—	—
30	MSS	F858L	300	V274F	66	—	—	—	—	—	—	—	—
31	MSS	R337H	20	—	—	A146T	140	—	—	—	—	—	—
32	MSS	R2912G	116	R2912G	400	—	—	G12S	120	—	—	—	—
33	MSS	G2695V	46	G245S	60	—	—	—	—	—	—	R1450Stop	50
34	MSS	V410A	132	R273C	108	G12V	—	—	—	—	—	R1450Stop	62
35	MSS	F858L	146	R282W	202	—	—	—	—	—	—	Q1291Stop	84

Abbreviations. HS: heterogeneity score. MSI: microsatellite instability. MSS: microsatellite stability.

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Table 2 Specific mutations found in ATM gene with concomitant “trunk” mutations (affecting TP53, KRAS, NRAS, BRAF and APC) with relative heterogeneity score.

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