Figure 2
From: Distinct isoforms of Nrf1 diversely regulate different subsets of its cognate target genes
Functional annotation of DEGs regulated by three Nrf1 isoforms. By GO analysis of Nrf1α-regulated DEGs, multilevel distribution is shown for the GO categories: “biological process” (A), “cellular component” (B) and “molecular function” (C). Similar categories were shown in the cases of Nrf1β-regulated DEGs (E–G) and Nrf1γ-regulated DEGs (I–K). The significant enriched GO terms presented in the pie charts are ranked by the number of DEGs, and the numerical values below each term are represented by the number of DEGs and P-value. The top-ranked 20 pathways enriched according to the Q value were plotted for Nrf1α-regulated DEGs (D), Nrf1β-regulated DEGs (H), and Nrf1γ-regulated DEGs (L). In the scatter plots, the rich factor is a ratio of DEGs’ number annotated in one pathway term to all genes’ number annotated in this pathway term. The Q value is corrected P-value ranging from 0 to 1, and less Q value means greater intensiveness. Furthermore, the number of DEGs mapped to the pathways, that were associated with carbohydrate metabolism, lipid metabolism, cancers, signal transduction, proteasome and redox signaling, was calculated in the stat chart (M).
