Figure 1
Gene expression changes in SOD1G93A and MLC/SOD1G93A mice. mRNA levels of target genes in Tibialis Anterior (TA) muscles of 90 days-old (A), 130 days old (B) SOD1G93A and (C) MLC/SOD1G93A mice (140 days-old). Data are expressed as Relative Fold Change (FC, calculated as [(Transgenic/ctrl value)-1]) versus the strain- and age-matched controls, of transcript levels performed by Real-Time PCR, for chloride channel ClC1, Protein Kinase C theta (PKC theta), Protein Kinase C alpha (PKC alpha), Ryanodine Receptor 1 (Ryr1), SERCA1, SERCA2, Calcineurin (CN), BK, Kir6.2, Sur1, Sur2, Sur2a, Sur2b, Nav1.4, Nmdar1, Ampar2, Murf1, Irisin, Notch1, TauT, Ampk, Nerve Growth Factor (NGF), Myostatin (Mstn) normalized by β-Actin housekeeping gene, in the 6 experimental groups. Each bar represents the FC ± S.E.M. Five muscles for each experimental group were analyzed and each muscle was analyzed in triplicate.
