Figure 2 | Scientific Reports

Figure 2

From: Ablation of glucocorticoid receptor in the hindbrain of the mouse provides a novel model to investigate stress disorders

Figure 2

HB-GRKO mice display severe barbering and cage stress. (A) Whole body examination shows excessive barbering to face and back in male and females, often resulting in broken skin and complete removal of whiskers. (B) Individually caged WT BL6 and LMC males displaying no hair loss or barbering. Individually caged HB-GRKO male shows excessive barbering and broken skin. (C) Histograph detailing distribution of genotypes and barbering severity in males, showing HB-GRKO mice with a barbering score of 3–5, compared to WT BL6 mice that fell between 0–1 on the scale. (D) Histograph detailing distribution of genotypes and barbering severity in females, showing HB-GRKO mice with a barbering score of 3–5, compared to WT BL6 mice that fell between 0–1 on the scale. (E) Observations of cage behaviour over a 5 minute period. WT BL6 animals can be seen exploring that cage with multiple rearing observed. HB-GRKO mice did little cage exploration and display obsessive behaviour via excessive and compulsive digging.

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