Table 4 KIRC Tumor Edges Associated with Co-Occuring VHL and PBRM1 Mutations.

From: Linking Binary Gene Relationships to Drivers of Renal Cell Carcinoma Reveals Convergent Function in Alternate Tumor Progression Paths

GeneA

GeneB

GeneA Description

GeneB Description

Module

Notes

ENSG00000160185;UBASH3A

ENSG00000153283;CD96

ubiquitin associated and SH3 domain containing A

CD96 molecule

TM0023

&,‡,†,*

ENSG00000183918;SH2D1A

ENSG00000160185;UBASH3A

SH2 domain containing 1A

ubiquitin associated and SH3 domain containing A

TM0023

%,‡,†,*

ENSG00000162739;SLAMF6

ENSG00000160185;UBASH3A

SLAM family member 6

ubiquitin associated and SH3 domain containing A

TM0023

&,‡,†,*

ENSG00000160185;UBASH3A

ENSG00000101082;SLA2

ubiquitin associated and SH3 domain containing A

Src like adaptor 2

TM0023

&,‡,†,*

ENSG00000160185;UBASH3A

ENSG00000116824;CD2

ubiquitin associated and SH3 domain containing A

CD2 molecule

TM0021

&,‡,†,*

ENSG00000160185;UBASH3A

ENSG00000089012;SIRPG

ubiquitin associated and SH3 domain containing A

signal regulatory protein gamma

TM0021

&,‡,†,*

ENSG00000277734;TRAC

ENSG00000160185;UBASH3A

T cell receptor alpha constant

ubiquitin associated and SH3 domain containing A

TM0021

&,‡,†,*

ENSG00000160185;UBASH3A

ENSG00000137078;SIT1

ubiquitin associated and SH3 domain containing A

signaling threshold regulating transmembrane adaptor 1

TM0021

&,‡,†,*

ENSG00000160185;UBASH3A

ENSG00000147168;IL2RG

ubiquitin associated and SH3 domain containing A

interleukin 2 receptor subunit gamma

TM0021

&,‡,†,*

ENSG00000167286;CD3D

ENSG00000160185;UBASH3A

CD3d molecule

ubiquitin associated and SH3 domain containing A

TM0021

&,‡,†,*

ENSG00000182866;LCK

ENSG00000160185;UBASH3A

LCK proto-oncogene, Src family tyrosine kinase

ubiquitin associated and SH3 domain containing A

TM0021

&,‡,†,*

ENSG00000198851;CD3E

ENSG00000160185;UBASH3A

CD3e molecule

ubiquitin associated and SH3 domain containing A

TM0021

&,‡,†,*

ENSG00000163564;PYHIN1

ENSG00000160185;UBASH3A

pyrin and HIN domain family member 1

ubiquitin associated and SH3 domain containing A

NA

&,‡,†,*

ENSG00000231890;DARS-AS1

ENSG00000227191;TCRGC2

DARS antisense RNA 1

T Cell Receptor Gamma Constant 2

NA

&,‡,†,*

ENSG00000281881;SPRY4-IT1

ENSG00000109920;FNBP4

SPRY4 intronic transcript 1

formin binding protein 4

NA

&,‡,†,*

ENSG00000161405;IKZF3

ENSG00000160185;UBASH3A

IKAROS family zinc finger 3

ubiquitin associated and SH3 domain containing A

NA

&,‡,†,*

ENSG00000160185;UBASH3A

ENSG00000143851;PTPN7

ubiquitin associated and SH3 domain containing A

protein tyrosine phosphatase, non-receptor type 7

NA

&,‡,†,*

ENSG00000160185;UBASH3A

ENSG00000104814;MAP4K1

ubiquitin associated and SH3 domain containing A

mitogen-activated protein kinase kinase kinase kinase 1

NA

&,‡,†,*

ENSG00000160185;UBASH3A

ENSG00000005844;ITGAL

ubiquitin associated and SH3 domain containing A

integrin subunit alpha L

NA

&,‡,†,*

ENSG00000263970;RP11-789C17.5

ENSG00000054148;PHPT1

Antisense RNA

phosphohistidine phosphatase 1

NA

&,‡,†,*

ENSG00000272505;RP11-981G7.6

ENSG00000253641;LINCR-0001

lincRNA

uncharacterized LINCR-0001

NA

&,‡,†,*

ENSG00000234290;AC116366.6

ENSG00000197536;C5orf56

Antisense RNA

chromosome 5 open reading frame 56

NA

&,‡,†,*

ENSG00000237721;AF064858.3

ENSG00000235888;AF064858.1

lincRNA

lincRNA

NA

&,‡,†,*

ENSG00000231233;CCDC147-AS1

ENSG00000184277;TM2D3

CCDC147 antisense RNA 1

TM2 domain containing 3

NA

&,‡,†,*

ENSG00000251320;AC011352.3

ENSG00000248362;AC011352.1

lncRNA

lncRNA

NA

&,‡,†,*

ENSG00000218227;RPL19P9

ENSG00000204677;FAM153C

Ribosomal Protein L19 Pseudogene 9

family with sequence similarity 153 member C

NA

&,‡,†,*

ENSG00000237471;AC073115.2

ENSG00000229628;AC073115.7

lincRNA

lincRNA

NA

&,‡,†,*

  1. &Spearman Correlation > 0.80; %Spearman Correlation < −0.80; ‡Padj KIRC Patient < 0.001; †Padj Primary Tumor < 0.001; *Padj VHL and PBRM1 Mutations < 0.001.