Figure 4
Measurements of co-expression with genes causing infertility. Differences in Manhattan (a,d,g) and Euclidean (b,c,e,f,h,i) distance values across 13 embryonic developmental stages between all duplicate gene pairs (a–c), all duplicate gene pairs obtained by the Blast search (d–f), and all mouse orthologues of human duplicate gene pairs (g–i) obtained from34. Euclidean distance was also measured using the normalised expression data (c,f,i). Here, distance indicates the co-expression level between duplicate gene pairs. Larger Manhattan and Euclidean distances indicate lower developmental co–expression between the two genes comprising a duplicate gene pair. (NE-I)-(NE-I) refers to all non-essential-non-essential genes pairs where no infertility-infertility (I-I) gene pair was present. The Kruskal-Wallis p-value for each analysis is reported below the corresponding graph.
