Figure 3 | Scientific Reports

Figure 3

From: Relevance of Titin Missense and Non-Frameshifting Insertions/Deletions Variants in Dilated Cardiomyopathy

Figure 3

Spatial distribution of rare TTN missense variants in DCM cohort and reference population. Titin is linearly depicted with its 152 Ig-like domains in purple and 132 fibronectin type III domains in green. TTN missense variants identified in patients as well as ExAC and gnomAD reference individuals are shown as coloured bars. Bisque bar represents the number of transcripts (TCI). Variants are shown relative to the Meta transcript position. The dark grey bars indicate exons unique to the Meta transcript. The dashed lines below the number of transcripts schematic indicate the location of variants within the sarcomere.

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