Table 1 Compounds identified in the Prestwick Compound Library that reduced DLK-GFP puncta per transfected cell (“Puncta/NLS”) by > 3xSD, relative to the mean of all compounds tested.
From: Identification of Novel Inhibitors of DLK Palmitoylation and Signaling by High Content Screening
Rank | Drug | Puncta per transfected cell (Read 1) | Puncta per transfected cell (Read 2) | Puncta per transfected cell (Mean) | Notes |
|---|---|---|---|---|---|
1 | Ketoconazole | 0.537 | 0.547 | 0.542 | Antifungal. Inhibits 17α-hydroxylase and 17,20-lyase activities of cytochrome P450 17A1, which are involved in steroid synthesis. |
2 | Lidoflazine | 0.687 | 0.588 | 0.637 | Ca2+ channel blocker. Coronary vasodilator. |
3 | Bromocryptine mesolate | 0.665 | 0.642 | 0.649 | Dopamine agonist. Also known as Parlodel. |
4 | Thioguanosine | 0.694 | 0.652 | 0.673 | Chemotherapeutic |
5 | Nefazodone HCl | 0.688 | 0.661 | 0.674 | 5-HT2A receptor antagonist |
6 | Sulconazole nitrate | 0.662 | 0.692 | 0.677 | Antifungal. Also known as Exelderm. |
7 | Nifedipine | 0.671 | 0.693 | 0.682 | Ca2+ channel blocker. Also known as Adalat. |
8 | Tyloxapol | 0.679 | 0.696 | 0.687 | Non-ionic polymer. Component of the expectorant Tacholiquin. |
9 | Disulfiram | 0.653 | 0.727 | 0.690 | Inhibits acetaldehyde dehrogenase. Also known as Antubuse and Antabus |
10 | Imatinib | 0.665 | 0.721 | 0.693 | Inhibts bcr-abl for treatment of chronic myelogenous leukemia. Also known as Gleevec |
11 | Clomiphene citrate (ZE) | 0.687 | 0.723 | 0.705 | Selective estrogen receptor modulator (SERM) |
