Table 1 The IC50 values of MJ and COR alone and CI values of the combination of MJ or COR with 2-DG (0.5 mM) against melanoma cells.

From: Metabolic and lipidomic investigation of the antiproliferative effects of coronatine against human melanoma cells

Cell line

MJ

COR

IC50 (μM)

CI

IC50 (μM)

CI

A375

13.18 ± 1.50

0.29

4.60 ± 0.51

0.33

A2058

37.94 ± 1.18

0.36

7.93 ± 1.50

0.39

  1. The IC50 and CI values were calculated using the CompuSyn software. The CI values were estimated from the combination effect data of 0.1 μM MJ + 0.5 mM 2-DG and 0.01 μM COR + 0.5 mM 2-DG. CI value of <1, 1, or >1 indicates synergistic, additive, or antagonistic effect, respectively. Data are expressed as mean ± SD of triplicate experiments. CI, combination index; COR, coronatine; 2-DG, 2-Deoxy-d-glucose; MJ, methyl jasmonate.
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