Figure 1 | Scientific Reports

Figure 1

From: The gut microbiota composition affects dietary polyphenols-mediated cognitive resilience in mice by modulating the bioavailability of phenolic acids

Figure 1The alt text for this image may have been generated using AI.

ABX treatment impairs cognitive function and reverse BDPP memory promoting effect. C57BL6 mice were randomly grouped into 6 groups: non sleep-deprived vehicle treated (Ctrl), sleep-deprived vehicle treated (SD), sleep-deprived BDPP treated (SD + BDPP), non sleep-deprived ABX treated (ABX), sleep-deprived ABX treated (SD + ABX), sleep-deprived treated with ABX in addition to BDPP (SD + ABX + BDPP). (a) Treatment scheme. Mice were sleep deprived for 5 h immediately after a fear conditioning training trial and tested for memory performance the next day. (b) Freezing percent across testing trial is significantly affected by sleep deprivation, BDPP and ABX treatment (1-way ANOVA, F(5,58) = 7.861, p < 0.0001). Sleep-deprived mice show decrease in freezing compared to both non sleep-deprived mice and sleep-deprived BDPP-treated mice (Tukey’s Multiple Comparison Test, *P < 0.05 Ctrl, n = 9 vs. SD, n = 10 and SD, n = 10 vs. SD + BDPP, n = 10). ABX treated mice showed reduced freezing compare to vehicle treated mice (Tukey’s Multiple Comparison Test, **P < 0.005 ABX, n = 9 vs. Ctrl, n = 9). ABX treatment reverse BDPP-mediated increase in freezing in sleep-deprived mice. (Tukey’s Multiple Comparison Test, *P < 0.05 SD + ABX + BDPP, n = 12 vs. SD + BDPP, n = 10). Data are means + SEM.

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