Figure 6
From: Involvement of TRPM2 and TRPM8 in temperature-dependent masking behavior
Possible neural circuit regulating temperature-dependent negative masking behavior in mice. Temperature information detected by thermosensors (e.g., TRPM2 and TRPM8) is sent to the thermoregulatory center, the POA, which sends direct and indirect (via DMH and/or SCN) projections to the aPVT/pPVT. The aPVT/pPVT and SCN are reciprocally connected. The aPVT/pPVT sends projections to the NAc, which is involved in the regulation of wheel-running behaviors. Arrows between nuclei indicate direct connections5,48,49,50,51,52,53,54,55,56. Note that TRPM2 is also expressed in the POA29.
