Table 2 Cluepedia enrichment of ClueGO protein-protein interaction network.

From: Gene expression analysis reveals early dysregulation of disease pathways and links Chmp7 to pathogenesis of spinal and bulbar muscular atrophy

GO ID

Ontology Source

GO Term

% Associated Genes

Adjusted p-value

GO:0051901

GO Biological Process

positive regulation of mitochondrial depolarization

37.500

0.008

GO:0035358

GO Biological Process

regulation of peroxisome proliferator activated receptor signaling pathway

18.182

0.022

GO:2000505

GO Biological Process

regulation of energy homeostasis

15.385

0.026

GO:0002090

GO Biological Process

regulation of receptor internalization

11.111

0.018

GO:0035567

GO Biological Process

non-canonical Wnt signaling pathway

10.526

0.011

GO:0050848

GO Biological Process

regulation of calcium-mediated signaling

7.500

0.029

GO:0031397

GO Biological Process

negative regulation of protein ubiquitination

6.122

0.038

GO:0046824

GO Biological Process

positive regulation of nucleocytoplasmic transport

6.024

0.017

GO:0006282

GO Biological Process

regulation of DNA repair

5.556

0.045

GO:0007043

GO Biological Process

cell-cell junction assembly

5.556

0.045

GO:0031929

GO Biological Process

TOR signaling

5.556

0.045

GO:0051897

GO Biological Process

positive regulation of protein kinase B signaling

5.063

0.034

GO:0051896

GO Biological Process

regulation of protein kinase B signaling

5.042

0.017

GO:0030177

GO Biological Process

positive regulation of Wnt signaling pathway

4.494

0.041

GO:0032388

GO Biological Process

positive regulation of intracellular transport

4.420

0.014

GO:0051222

GO Biological Process

positive regulation of protein transport

4.348

0.009

GO:0005758

GO Cellular Component

mitochondrial intermembrane space

5.455

0.046

GO:0019199

GO Molecular Function

transmembrane receptor protein kinase activity

4.819

0.036

KEGG:04012

KEGG

ErbB signaling pathway

4.598

0.039

KEGG:04512

KEGG

ECM-receptor interaction

4.545

0.040

REACTOME:5892997

REACTOME

Methylation

20.000

0.020

REACTOME:5893278

REACTOME

mTORC1-mediated signalling

10.526

0.038

REACTOME:5892940

REACTOME

IGF1R signaling cascade

4.082

0.050