Table 3 GSEA analysis.

From: Gene expression analysis reveals early dysregulation of disease pathways and links Chmp7 to pathogenesis of spinal and bulbar muscular atrophy

Name

Size

ES

NES

p-value

Adjusted p-value 

(A) Pathways enriched in AR 100 motor neuron

KEGG ECM receptor interaction

75

0.680

2.364

0

0

KEGG cell cycle

111

0.628

2.348

0

0

KEGG focal adhesion

180

0.570

2.260

0

0

KEGG DNA replication

32

0.682

2.066

0

0

KEGG small cell lung cancer

79

0.576

1.989

0

0.002

KEGG p53 signalling pathway

60

0.577

1.975

0

0.002

KEGG regulation of actin cytoskeleton

187

0.478

1.883

0

0.008

KEGG pathways in cancer

305

0.455

1.883

0

0.007

KEGG lysosome

109

0.490

1.817

0

0.015

KEGG lysine degradation

42

0.548

1.742

0.002

0.031

KEGG basal cell carcinoma

54

0.518

1.699

0.003

0.045

BioCarta GSK3 pathway

27

0.676

1.942

0.002

0.028

BioCarta cell cycle pathway

21

0.696

1.899

0

0.027

BioCarta G1 pathway

26

0.660

1.885

0

0.021

BioCarta integrin pathway

38

0.598

1.825

0

0.042

BioCarta ALK pathway

35

0.598

1.825

0.002

0.034

BioCarta p38 MAPK pathway

38

0.594

1.819

0

0.030

BioCarta HIV nef pathway

53

0.545

1.806

0

0.030

(B) Pathways decreased in AR 100 motor neurons

KEGG neuroactive ligand receptor interaction

22

−0.427

−1.936

0

0.007

KEGG regulation of autophagy

24

−0.493

−1.504

0.038

0.302

KEGG autoimmune thyroid disease

23

−0.487

−1.447

0.045

0.305