Table 5 Genotype and allele distribution of NLRP3 (Q705K) and CARD8 (C10X) in relation to treatment outcome in all patients with active tuberculosis (TB).
Locus | Genotype/allele | Poor outcome, n (%) | Successful outcome, n (%) | OR (95% CI) | p |
|---|---|---|---|---|---|
NLRP3 (Q705K) | CC | 16 (76.2) | 602 (90.7) | 0.32 (0.11–0.93) | 0.036 |
rs35829419 | CA | 5 (23.8) | 61 (9.2) | 3.1 (1.1–8.7) | 0.033 |
AA | 0 (100) | 1 (0.1) | — | — | |
C | 21 (80.8) | 663 (91.4) | 0.39 (0.14–1.1) | 0.070 | |
A | 5 (19.2) | 62 (8.6) | 2.5 (0.92–7.0) | 0.070 | |
CARD8 (C10X) | AA | 6 (35.3) | 227 (37.2) | 0.92 (0.34–2.5) | 0.872 |
rs2043211 | AT | 8 (47.1) | 292 (47.9) | 0.97 (0.37–2.5) | 0.947 |
TT | 3 (17.6) | 91 (14.9) | 1.2 (0.34–4.3) | 0.756 | |
A | 14 (56.0) | 519 (57.5) | 0.93 (0.42–2.1) | 0.878 | |
T | 11 (44.0) | 383 (42.5) | 1.1 (0.50–2.4) | 0.878 |
