Table 4 Association of F5 diplotypes with quantitative biological phenotypes in MARTHA GWAS and MARTHA 12.

From: Minor allele of the factor V K858R variant protects from venous thrombosis only in non-carriers of factor V Leiden mutation

Diplotype

Log ACVn*

FV plasma levels (IU/mL)

n

 

p

n

 

p

H1H1

450

0.051 (0.235)

Ref

480

1.09 (0.236)

Ref

H1H2

87

−0.723 (0.210)

1.79 10−169

98

1.09 (0.261)

0.42

H2H3

29

−0.700 (0.193)

1.00 10−59

31

1.13 (0.268)

0.20

H1H3

281

0.072 (0.261)

0.14

293

1.07 (0.210)

0.18

H3H3

39

0.096 (0.244)

0.20

42

1.05 (0.149)

0.53

  1. H1 haplotype refers to the R534/K858 haplotype. H2 haplotype represents the unique haplotype carrying the FV Leiden mutation (Q534/K858). H3 haplotype represents the unique haplotype carrying the rare R858 allele (R534/R858).
  2. ACVn: normalized Agkistrodon Contortrix Venom ratio; FV: Factor V.
  3. Association analyses were adjusted for age, sex and MARTHA substudy group. *Analyses were conducted after excluding individuals under anticoagulant therapy.
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