Figure 4 | Scientific Reports

Figure 4

From: Alterations in the tyrosine and phenylalanine pathways revealed by biochemical profiling in cerebrospinal fluid of Huntington’s disease subjects

Figure 4

Associations between the biochemical changes and HD symptoms, where a ‘*’ indicates a corresponding p-value < 0.05. Hierarchical clustering has been performed on the correlation values where metabolites from the tyrosine metabolism, phenylalanine metabolism as well as the purine metabolism have been marked. DBS: disease burden score; TFC: total functional capacity; 5yrisk: the five year risk of onset; TMS: total motor score; SC: Stroop color; SWR: Stroop word reading; SI: Stroop interference; CVF: category verbal fluency; VFL: verbal fluency letters; SDMT: symbol digit modalities test. *Metabolites with a demonstrated age dependence that have been corrected.

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