Table 5 Results from the pathway analysis based on the altered metabolites in manifest HD patients compared with premanifest HD subjects. p-values < 0.05 and FDR values < 0.1 have been bolded.
Pathway | Coverage | p-value | FDR | Impact |
|---|---|---|---|---|
Aminoacyl-tRNA biosynthesis | 6/75 | 2.8 × 10 −5 | 2.2 × 10 −3 | 0.0 |
Phenylalanine, tyrosine and tryptophan biosynthesis | 3/27 | 1.5 × 10 −3 | 0.039 | 0.008 |
Valine, leucine and isoleucine biosynthesis | 3/27 | 1.5 × 10 −3 | 0.039 | 0.040 |
Tyrosine metabolism | 4/76 | 3.7 × 10 −3 | 0.061 | 0.182 |
Nitrogen metabolism | 3/39 | 4.3 × 10 −3 | 0.061 | 0.0 |
Valine, leucine and isoleucine degradation | 3/40 | 4.6 × 10 −3 | 0.061 | 0.022 |
Phenylalanine metabolism | 3/45 | 6.4 × 10 −3 | 0.073 | 0.173 |
Purine metabolism | 4/92 | 7.3 × 10 −3 | 0.073 | 0.059 |
