Table 1 Critical miRNA identified and predicted downstream gene expression targets for sensorineural hearing loss vs conductive hearing loss.
miRNA 182 | Entrez Gene Name | Location | Family | miRNA - mRNA Match |
|---|---|---|---|---|
ADCY6 | Adenylate Cyclase 6 | Plasma Membrane | enzyme | Proven |
IGF1R | Insulin Like Growth Factor 1 Receptor | Plasma Membrane | transmembrane receptor | Proven |
MITF | Melanogenesis Associated Transcription Factor | Nucleus | transcription regulator | Proven |
MTDH | Metadherin | Cytoplasm | transcription regulator | Proven |
PPARA | Peroxisome Proliferator Activated Receptor Alpha | Nucleus | ligand-dependent nuclear receptor | Proven |
RARG | Retinoic Acid Receptor Gamma | Nucleus | ligand-dependent nuclear receptor | Proven |
TP53 | Tumor Protein p53 | Nucleus | transcription regulator | Proven |
miRNA 4278 | ||||
ARCN1 | archain 1 | Cytoplasm | other | High Probability |
CASC4 | cancer susceptibility 4 | Cytoplasm | other | High Probability |
CD81 | CD81 molecule | Plasma Membrane | other | High Probability |
EIF4A1 | eukaryotic translation initiation factor 4A1 | Cytoplasm | translation regulator | High Probability |
FOSB | FosB proto-oncogene, AP-1 transcription factor subunit | Nucleus | transcription regulator | High Probability |
GDI1 | GDP dissociation inhibitor 1 | Cytoplasm | other | High Probability |
HSP90B1 | heat shock protein 90 beta family member 1 | Cytoplasm | other | High Probability |
KAT2B | lysine acetyltransferase 2B | Nucleus | transcription regulator | High Probability |
NT5DC3 | 5′-nucleotidase domain containing 3 | Other | other | High Probability |
RHOC | ras homolog family member C | Plasma Membrane | enzyme | High Probability |
SRSF2 | serine and arginine rich splicing factor 2 | Nucleus | transcription regulator | High Probability |
STOM | stomatin | Plasma Membrane | other | High Probability |
THRA | thyroid hormone receptor, alpha | Nucleus | ligand-dependent nuclear receptor | High Probability |
miRNA 3975 | ||||
ACTG1 | actin gamma 1 | Cytoplasm | other | High Probability |
BSG | basigin (Ok blood group) | Plasma Membrane | transporter | High Probability |
DCTN5 | dynactin subunit 5 | Cytoplasm | other | High Probability |
EPS15 | epidermal growth factor receptor pathway substrate 15 | Cytoplasm | other | High Probability |
GJB2 | gap junction protein beta 2 | Plasma Membrane | transporter | High Probability |
IFI6 | interferon alpha inducible protein 6 | Cytoplasm | other | High Probability |
PPP1R1B | protein phosphatase 1 regulatory inhibitor subunit 1B | Cytoplasm | phosphatase | High Probability |
SC5D | sterol-C5-desaturase | Cytoplasm | enzyme | High Probability |
miRNA 4655 | ||||
CDC42 | cell division cycle 42 | Cytoplasm | enzyme | High Probability |
FAM126A | family with sequence similarity 126 member A | Cytoplasm | other | High Probability |
FOXO1 | forkhead box O1 | Nucleus | transcription regulator | High Probability |
GPX1 | glutathione peroxidase 1 | Cytoplasm | enzyme | High Probability |
NFIX | nuclear factor I X | Nucleus | transcription regulator | High Probability |
SERPINF1 | serpin family F member 1 | Extracellular Space | other | High Probability |
THRA | thyroid hormone receptor, alpha | Nucleus | ligand-dependent nuclear receptor | High Probability |
UBE3A | ubiquitin protein ligase E3A | Nucleus | enzyme | High Probability |
XRCC6 | X-ray repair cross complementing 6 | Nucleus | enzyme | High Probability |
