Figure 2 | Scientific Reports

Figure 2

From: Cyclosporin A ameliorates cerebral oxidative metabolism and infarct size in the endothelin-1 rat model of transient cerebral ischaemia

Figure 2

Temporal patterns of microdialysis metabolite concentrations – treatment vs placebo. Timeline graphs with normalised baselines showing the dynamic changes of brain interstitial mean (±SEM) concentrations of main intermediate metabolites of the redox-state in CsA (n = 10) and placebo (n = 7) specimens. At 1 hour, transient cerebral ischaemia was induced through intracerebral microinjection of ET-1. (A) Glucose levels showed similar patterns of transient ischaemia/reperfusion in both groups. (B) Lactate levels were very similar in the two groups, with low variance and a tendency to lower post-ischaemic values in the treatment group. (C) Pyruvate levels with the characteristic dip and overshoot pattern of this model, with CsA-treated animals showing slightly higher values. (D) The primary outcome variable LPR showed a significant point difference of 60.6 ± 24.3% at 3–5 hours (p = 0.013, mixed effect regression analysis). CsA = cyclosporin A, ET-1 = endothelin-1, LPR = lactate/pyruvate ratio.

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