Figure 4
From: Exploiting heat shock protein expression to develop a non-invasive diagnostic tool for breast cancer
HS-27 fluorescence is greater in tumor than non-tumor tissue. (a) CDFs of fluorescence image pixel intensities were created for each combined biopsy image of either all pixels or of only the top 25%, top 10%, or top 1% of pixels. Curves were stratified by histology type. Mammoplasty (black) survival curves were significantly different from tumor curves by KS testing across pixel bins. (b,c) Box plots of intensity summary parameters mean, variance and max to min ratio for tumor (T), benign (b) and mammoplasty (M) biopsies for (b) all pixels or (c) the top 1% of pixels. Sample sizes – n = 6 mammoplasty, n = 10 benign, n = 27 tumor. *p < 0.05 by KS testing (CDFs) or one-way ANOVA with Tukey-Kramer post-hoc testing (box plots). Survival curves show the mean ± SEM.
