Figure 1
From: Global response of diacylglycerol kinase towards substrate binding observed by 2D and 3D MAS NMR
Physiological role of E.coli diacylglycerol kinase (DGK) in recycling during the biosynthesis of membrane-derived oligosaccharides (MDOs)1,2. MDOs are largely generated in response to environmental stress, such as low osmolarity4,5. DGK is located within the inner membrane, where it catalyzes the ATP-dependent phosphorylation of potentially membrane-disruptive diacylglycerol (DAG) to non-toxic phosphatic acid (PA). It provides the basis for restoring phosphatidylglycerol (PG), which is consumed in the MDO cycle. The cartoon is based on the X-ray structure using the PDB ID 4UXX11.
