Figure 2 | Scientific Reports

Figure 2

From: ALDH1A1 regulates postsynaptic μ–opioid receptor expression in dorsal striatal projection neurons and mitigates dyskinesia through transsynaptic retinoic acid signaling

Figure 2

A loss of MOR1 expression in dorsal striatum occurs in postnatal and adult Aldh1a1−/− mice. (A) Representative images show MOR1 staining in the selective striatal coronal sections of Aldh1a1+/+ and Aldh1a1−/− mice at different age. Scale bar: 1000 μm. (B,C) Box and whiskers plots (min to max) show the signal intensities of MOR1 staining in the DS (B) and VS (C) of Aldh1a1+/+ and Aldh1a1−/− mice at different ages (n = 5 animals per genotype per age group, 3 sequential coronal sections between Bregma 0.84–1.10 per animal). Data were presented as mean ± SEM. Two-way ANOVA was used for statistical analysis, followed by Bonferroni’s post hoc tests. Genotype factor: DS, F(1, 111) = 1347.42, ****p < 0.0001; VS, F(1, 24) = 61.20, ****p < 0.0001.

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