Figure 6 | Scientific Reports

Figure 6

From: ALDH1A1 regulates postsynaptic μ–opioid receptor expression in dorsal striatal projection neurons and mitigates dyskinesia through transsynaptic retinoic acid signaling

Figure 6

Open-field tests of Aldh1a1+/+ and Aldh1a1−/− mice. (A) Line graphs quantify the ambulation, rearing, and fine movement of 3–month–old Aldh1a1+/+ (n = 14) and Aldh1a1−/− (n = 14) mice. Data were presented as mean ± SEM. Two-way ANOVA followed by Bonferroni multiple comparisons test: ambulation, F(1, 26) = 1.00, p = 0.3559; rearing, F(1, 26) = 17.95, p = 0.0003; fine, F(1, 26) = 10.51, p = 0.0032. (B) Open-field tests of 3–month–old Aldh1a1−/− mice treated with oil (n = 10) or RA (n = 12). Data were presented as mean ± SEM. Two-way ANOVA followed by Bonferroni multiple comparisons test: ambulation, F(1, 60) = 0.26, p = 0.9596; rearing, F(1, 60) = 0.91, p = 0.7299; fine, F(1, 60) = 0.15, p = 0.7022.

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