Figure 5

Schematic illustration of the intestine specific promoter (Pi) 5′pcmah-1 and the house-keeping (constitutive) promoter (Ph) 5′pcmah-2 of the pcmah gene. The housekeeping promoter region of pcmah, starting at the 5′ flanking region including 3 independent SP1 of Exon 0, regulates the constitutive expression of 5′pcmah-2. Intestine specific splicing variant of pcmah (5′pcmah-1) is stringently controlled by the intestine specific promoter P1, starting at the 5′ flanking region, including Ets-1 and SP1 of Exon 1a.