Figure 1
From: Cargo diffusion shortens single-kinesin runs at low viscous drag
Cargo diffusion shortens single-kinesin run length at low viscosities (A) by imposing substantial assisting load on the motor (B). Simulations were carried out using a cargo 0.5 µm in diameter and a motor velocity of 0.8 µm/s unloaded. ηwater, the viscosity of water. (A) Run length (mean ± standard error of the mean) was normalized by the unloaded single-kinesin run length. N = 1000 for each simulation condition. Grey area, the difference in run length between simulations with and without cargo diffusion. Vertical dashed line, a viscosity 22-fold higher than that of water (22·ηwater). (B) Thermal diffusion of the cargo increases the load on the motor at low viscosities. Positive values indicate load in the direction that assists motor movement; negative values indicate load in the direction that hinders motor movement.
