Table 2 Comparison of clinical characteristics between sessile serrated adenomas/polyps without and with dysplasia or adenocarcinoma groups.
Variables | Frequency (%) or mean ± SD | P value | |
|---|---|---|---|
SSA/POs (n = 370) | SSA/PDAs (n = 162) | ||
Patient factors | |||
Age (years) [mean ± SD] (range) | 57.8 ± 12.4 (23.0–85.0) | 58.6 ± 12.7 (31.0–90.0) | 0.475 |
Sex | 0.503 | ||
Male | 210 (56.8) | 97 (59.9) | |
Female | 160 (43.2) | 65 (40.1) | |
BMI (n = 499) [mean ± SD] (range) | 24.3 ± 4.1 (14.3–55.0) | 23.5 ± 3.2 (14.4–39.0) | 0.019 |
Alcohol (n = 498) | 0.629 | ||
No | 202 (59.6) | 95 (59.7) | |
Yes | 137 (40.4) | 64 (40.3) | |
Smoking (n = 500) | 0.718 | ||
No | 226 (66.3) | 110 (69.2) | |
Yes | 115 (33.7) | 49 (30.8) | |
Regular aspirin or NSAIDs use (n = 511) | 0.736 | ||
No | 290 (83.1) | 130 (80.2) | |
Yes | 59 (16.9) | 32 (19.8) | |
Lesion factors | |||
Location | 0.002 | ||
Proximal | 238 (64.3) | 81 (50.0) | |
Distal | 132 (35.7) | 81 (50.0) | |
Location (Subsites) | 0.004 | ||
Cecum | 41 (11.1) | 12 (7.4) | |
Ascending colon | 124 (33.5) | 47 (29.0) | |
Transverse colon | 73 (19.7) | 22 (13.6) | |
Descending colon | 30 (8.1) | 8 (4.9) | |
Sigmoid colon | 72 (19.5) | 47 (29.0) | |
Rectum | 30 (8.1) | 26 (16.0) | |
Size (mm) [mean ± SD] (range) | 10.6 ± 7.4 (2.0–40.0) | 10.9 ± 7.6 (2.0–50.0) | 0.625 |
Proximal colon | 11.4 ± 7.3 | 10.9 ± 7.6 | 0.350 |
Distal colon | 9.2 ± 7.5 | 11.0 ± 7.6 | 0.825 |
Size (mm) [mean ± SD] (range) (Subsites) | |||
Cecum | 10.6 ± 7.9 | 13.2 ± 10.0 | 0.717 |
Ascending colon | 11.9 ± 6.7 | 10.4 ± 5.6 | 0.189 |
Transverse colon | 11.0 ± 7.8 | 10.9 ± 9.7 | 0.872 |
Descending colon | 9.4 ± 7.3 | 9.1 ± 4.8 | 0.486 |
Sigmoid colon | 9.4 ± 7.8 | 10.7 ± 8.5 | 0.817 |
Rectum | 8.6 ± 6.9 | 12.1 ± 6.8 | 0.615 |
Morphology (Paris classification) | <0.001 | ||
0-Ip | 25 (6.8) | 27 (16.7) | |
0-Isp | 47 (12.7) | 29 (17.9) | |
0-Is | 169 (45.7) | 65 (40.1) | |
0-IIa | 119 (32.2) | 32 (19.8) | |
0-IIb | 2 (0.5) | 3 (1.9) | |
0-IIa + IIc | 8 (2.2) | 6 (3.7) | |
Endoscopic features | |||
Nodular surface | 127 (34.3) | 117 (72.2) | <0.001 |
Disrupted vascular pattern | 147 (39.7) | 85 (52.5) | 0.006 |
Altered fold contour | 100 (27.0) | 41 (25.3) | 0.679 |
Dome-shaped morphology | 98 (26.5) | 37 (23.0) | 0.394 |
Pale color | 82 (23.2) | 29 (17.9) | 0.168 |
Mucus cap | 46 (12.4) | 16 (9.9) | 0.398 |
Rim of debris/bubbles | 28 (7.6) | 4 (2.5) | 0.023 |
Associated lesions | |||
TSA | 26 (7.0) | 4 (2.5) | 0.036 |
Hyperplastic polyp | 96 (25.9) | 33 (20.4) | 0.167 |
Conventional adenoma with LGD | 126 (34.1) | 84 (51.9) | <0.001 |
Conventional adenoma with HGD + ADC | 26 (7.0) | 19 (11.7) | 0.090 |
Advanced adenoma | 37 (10.0) | 20 (12.3) | 0.421 |
Procedure factors | |||
Removal method | 0.001 | ||
Polypectomy | 82 (22.2) | 13 (8.0) | |
EMR | 271 (73.2) | 141 (87.0) | |
EPMR | 4 (1.1) | 1 (0.6) | |
ESD | 13 (3.5) | 7 (4.3) | |
Post-procedural complication | 0.006 | ||
Bleeding | 15 (4.1) | 18 (11.2) | |
Perforation | 2 (0.5) | 0 (0.0) | |
