Figure 2
From: Cationic gold nanoparticles elicit mitochondrial dysfunction: a multi-omics study
Cell viability and survival assessment. THP-1 cells were exposed for 24 h to Au-5 nm NPs (A) and Au-20 nm NPs (B). The percentage of living cells were determined by using the Alamar Blue assay. Data shown are mean values ± S.D. from 3 individual experiments each performed in triplicate. *p < 0.05 compared to control. (C) The survival rates of C. elegans N2 animals treated with Au-COOH NPs and Au-NR3+ NPs at the indicated concentrations for 24 h. The number of animals that survived was scored after treatment. 25 animals were scored for each concentration. Data shown are mean values ± S.D. from 3 individual experiments. (D) The effects of Au-NR3+ NPs (at 500 μg/mL) on animals defective for the selected cell death pathways (the ced-3(n2433) mutation blocks the apoptosis pathway, the clp-1(tm690) mutation blocks the necrosis pathway, and the lgg-1(bp500) mutations blocks the autophagy pathway). 25 animals were treated in each experiment. Data shown are mean values ± S.D. from 3 individual experiments. *P < 0.05.
