Table 1 Effects of rivaroxaban on body weight, metabolic profile and thrombin generation.
14 weeks WTD | 14 weeks WTD + Riva | p-value | 20 weeks WTD | p-value | 20 weeks WTD + Riva | p-value | |
|---|---|---|---|---|---|---|---|
Body weight (g) | 22 (21–24) | 23 (22–25) | 0.3726 | 24 (23–26) | 0.0446* | 24 (23–25) | 0.0138* |
Rivaroxaban level (ug/L) | 217 (156–349) | 240 (150–247) | |||||
Lipid profile | |||||||
Total cholesterol (mmol/L) | 18.25 (16.72–23.58) | 20.71 (19.50–23.40) | 0.4000 | 24.62 (22.10–27.67) | 0.1111 | 22.50 (20.20–25.13) | 0.3429 |
TGL (mmol/L) | 0.47 (0.39–0.63) | 0.42 (0.41–0.47) | 0.5714 | 0.62 (0.48–0.74) | 0.4603 | 0.58 (0.50–0.62) | 0.4857 |
LDL (mmol/L) | 15.35 (13.10–22.70) | 16.80 (16.50–23.20) | 0.3456 | 19.90 (18.00–23.10) | 0.4524 | 17.30 (16.65–22.23) | 0.3429 |
HDL (mmol/L) | 5.15 (3.22–5.52) | 6.45 (4.73–7.45) | 0.4238 | 6.15 (2.67–6.72) | 0.2857 | 5.89 (4.95–7.89) | 0.4429 |
Thrombin generation | |||||||
Lag time (min) | 2.08 (1.82–2.29) | 3.24 (2.61–3.50) | <0.0001* | 2.33 (2.00–2.37) | 0.1322 | 3.33 (3.08–3.46) | 0.0002* |
Peak height (nmol/L) | 71.65 (67.02–82.01) | 67.88 (64.21–69.59) | 0.0684 | 89.40 (82.54–94.51) | 0.0127* | 71.71 (61.70–77.72) | 0.7023 |
ETP (nmol/L.min) | 451 (413–476) | 498 (405–574) | 0.0322* | 456 (411–534) | 0.8272 | 409 (376–431) | 0.0432* |
