Figure 2 | Scientific Reports

Figure 2

From: PGC-1α overexpression partially rescues impaired oxidative and contractile pathophysiology following volumetric muscle loss injury

Figure 2

Significant changes and structural disruptions in the muscle remaining following VML injury. The effects of VML on mitochondrial organization were evaluated at various time points in control muscle and muscle remaining after VML injury. Two biological replicates representative 3D reconstructions of the mitochondrial network as observed in uninjured control muscle (a) and from the injury boundary in VML injured muscle at (b) 3, (c) 7, and (d) 28 days post-VML. Longitudinal striations are visible in uninjured control muscle indicating the high level of mitochondrial network organization, which is absent in the VML-injured muscle at 3 and 7 days after the injury.

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