Figure 3 | Scientific Reports

Figure 3

From: PGC-1α overexpression partially rescues impaired oxidative and contractile pathophysiology following volumetric muscle loss injury

Figure 3

The mitochondrial network organization is altered by VML injury. (a) Schematics representing control and VML injured TA muscle, showing the region of interest evaluated during imaging and representative 2D images from the respective regions from transgenic mice that ubiquitously expressed mitochondrial Dendra2 GFP. (b) Representative 3D reconstruction of mitochondrial network adjacent to the VML injury site from control and VML injured TA muscles. (c) Representative 3D surface plots showing angle and alignment strength of the 3D mitochondrial network depicted. (d) Quantification of mitochondrial network organization (peak alignment/average alignment) at various time points after injury (n > 10 z-stacks per muscle, per group). Data analyzed by one-way ANOVA, *P < 0.05. Error bars represent means ± SD.

Back to article page