Figure 4 | Scientific Reports

Figure 4

From: A Novel Lactate Dehydrogenase Inhibitor, 1-(Phenylseleno)-4-(Trifluoromethyl) Benzene, Suppresses Tumor Growth through Apoptotic Cell Death

Figure 4

Formation of LDHA complex with NADH, pyruvate, or PSTMB and their overall modeled structures. (A) Schematic representations of LDHA complexed with NADH, pyruvate, or PSTMB are shown. (B) Ribbon and surface representations (left and middle panels) of the modeled structure of LDHA with NADH and pyruvate are shown. The interaction sites of the LDHA complex with NADH and pyruvate are shown (right panel). (C) The inhibitor PSTMB is bound to LDHA at the opposite site hole of the active site where pyruvate binds. The relative distribution of the surface charge is shown with the acidic region in red, basic region in blue and neutral region in white (middle panel).

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