Figure 4 | Scientific Reports

Figure 4

From: H727 cells are inherently resistant to the proteasome inhibitor carfilzomib, yet require proteasome activity for cell survival and growth

Figure 4

Effect of IFN-γ pretreatment on carfilzomib sensitivity of H727 (a) and H23 (b) cells. IFN-γ (150 U⋅ml−1) pretreatment for 24 h led to increased expression (left panel) and activity (middle panel) of proteasome immuno-subunits, and sensitized H727 cells to Cfz, while desensitizing H23 cells towards Cfz. The IC50 values displayed a statistically significant difference between IFN-γ-pretreated cells and vehicle control (P value < 0.01, n = 3, Student’s t-test comparing the log transformed IC50 values obtained from three independent runs).

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