Table 2 Correlation coefficients of circulating trimethylamine N-oxide (TMAO) concentration, flow-mediated dilation (FMD), and various clinical variables.

From: Trimethylamine N-Oxide, Circulating Endothelial Progenitor Cells, and Endothelial Function in Patients with Stable Angina

Variables

TMAO

FMD

R

P value

R

P value

Clinical variables

  Age (years)

0.044

0.693

0.117

0.297

  Body mass index (kg/m2)

−0.035

0.756

0.028

0.804

  Hemoglobin (g/dL)

−0.210

0.059

0.021

0.852

  eGFR (mL/min/1.73 m2)

−0.279

0.012

0.284

0.011

  Fasting glucose (mg/dL)

0.177

0.126

−0.007

0.954

  Total cholesterol (mg/dL)

−0.166

0.141

0.153

0.175

  Triglyceride (mg/dL)

0.198

0.078

−0.084

0.457

  Uric acid (mg/dL)

0.004

0.972

0.067

0.555

Cardiac catheterization

  SYNTAX score

0.244

0.034

−0.145

0.211

  LVEDP (mmHg)

0.059

0.636

−0.146

0.238

  LVEF (%)

−0.207

0.063

0.123

0.272

Inflammatory biomarkers

  hsCRP (mg/dL)

0.276

0.013

−0.450

<0.001

  IL-1β (pg/mL)

0.332

0.003

−0.550

<0.001

  TMAO (μmol/L)

—

—

−0.377

0.001

Endothelial functions

  CD34+, KDR+ cells (%)

−0.260

0.019

0.307

0.005

  CD34+, KDR+, CD133+ cells (%)

−0.245

0.028

0.275

0.013

  Flow-mediated dilation (%)

−0.377

0.001

—

—

  1. eGFR, estimated glomerular filtration rate; LVEDP, left ventricular end-diastolic pressure; LVEF, left ventricular ejection fraction; hsCRP, high-sensitivity C-reactive protein; IL-1β, interkeukin-1β; KDR, kinase-insert domain-containing receptor.
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