Figure 4

Epigenetic regulation of gene expression. (a) DEGs involved in DNA methylation. The process is divided in sub-processes (purple ovals) and depicting involved genes (blue rectangles) and detected DEGs for cardiac (orange rectangles) and hepatic (green rectangles) samples. (b) Relative enrichment of DMRs (DMSO vs UNTR, FDR 5%) within genomic features. For each feature, the number of overlapping DMRs over the total number of tested windows for the respective feature is depicted. Compared to all genomic regions, hypermethylated regions are enriched for satellites, simple repeats, and CGIs distal to promoters without known regulatory evidence and hypomethylated regions are enriched for simple repeats.