Table 1 Pathway analysis of Cardiac DEGs & DEPs detected after 0.1% DMSO exposure.
From: DMSO induces drastic changes in human cellular processes and epigenetic landscape in vitro
Cluster name (stable identifier) | Set size | Ranking (DEGs) | Amount DEGs (%) | Amount DEGs (%)|log2FC| > 1 | q-value | % DEGs Down-regulated |
|---|---|---|---|---|---|---|
Cellular responses to stress (R-HSA-2262752) | 393 | 1 | 91 (23.5%) | 28 (7.1%) | 2.2E-09 | 61.5 |
Disease (R-HSA-1643685) | 514 | 2 | 109 (21.5%) | 33 (6.4%) | 4.5E-09 | 61.5 |
Vesicle-mediated transport (R-HSA-5653656) | 619 | 3 | 122 (20.0%) | 48 (7.8%) | 2.7E-08 | 55.7 |
Metabolism of proteins (R-HSA-392499) | 1506 | 4 | 236 (16.0%) | 80 (5.3%) | 9.3E-07 | 68.2 |
Chromatin organization (R-HSA-4839726) | 274 | 5 | 58 (21.3%) | 19 (6.9%) | 5.2E-05 | 53.4 |
Muscle contraction (R-HSA-397014) | 198 | 6 | 41 (21.0%) | 11 (5.6%) | 9.5E-04 | 63.4 |
Gene Expression (R-HSA-74160) | 1755 | 7 | 235 (13.7%) | 76 (4.3%) | 6.6E-03 | 55.7 |
Metabolism (R-HSA-1430728) | 2035 | 8 | 269 (13.5%) | 100 (4.9%) | 7.9E-03 | 69.1 |
Extracellular matrix organization (R-HSA-1474244) | 295 | 9 | 51 (17.6%) | 23 (7.8%) | 8.1E-03 | 52.9 |
Immune System (R-HSA-168256) | 1950 | 10 | 257 (13.5%) | 95 (4.9%) | 9.7E-03 | 68.1 |
Cell Cycle (R-HSA-1640170) | 551 | 11 | 85 (15.7%) | 34 (6.2%) | 1.0E-02 | 54.1 |
DNA Repair (R-HSA-73894) | 323 | 12 | 54 (17.1%) | 17 (5.3%) | 1.1E-02 | 61.1 |
Organelle biogenesis and maintenance (R-HSA-1852241) | 310 | 13 | 50 (16.5%) | 20 (6.5%) | 2.7E-02 | 66 |
Developmental Biology (R-HSA-1266738) | 748 | 14 | 104 (14.1%) | 33 (4.4%) | 5.6E-02 | 57.7 |
Hemostasis (R-HSA-109582) | 693 | 15 | 97 (14.2%) | 36 (5.2%) | 5.6E-02 | 68 |
Cell-Cell communication (R-HSA-1500931) | 131 | 16 | 22 (17.1%) | 7 (5.3%) | 1.1E-01 | 68.2 |
Transport of small molecules (R-HSA-382551) | 628 | 17 | 75 (12.1%) | 28 (4.5%) | 4.4E-01 | 65.3 |
Neuronal System (R-HSA-112316) | 351 | 18 | 34 (9.8%) | 13 (3.7%) | 9.2E-01 | 47.1 |
Signal transduction (R-HSA-162582) | 2538 | 19 | 260 (10.4%) | 93 (3.7%) | 9.9E-01 | 58.1 |
