Table 5 The 7 common targets associated with the most drugs known for the treatment of pain.

From: A bioinformatics investigation into the pharmacological mechanisms of the effect of Fufang Danshen on pain based on methodologies of network pharmacology

Gene

Protein

Compound

Type

PTGS2

Prostaglandin G/H synthase 2

Hexadecanoic acid, eicosatetraenoic acid

successful

PTGS1

Prostaglandin G/H synthase 1

Eicosatetraenoic acid

successful

HTR3A

5-hydroxytryptamine receptor 3A

Ginsenoside Rg3

successful

NR3C1

Glucocorticoid receptor

Ginsenoside Re

investigational

CHRNA7

Neuronal acetylcholine receptor subunit alpha-7

Ginsenoside Rg1

investigational

TOP2A

DNA topoisomerase 2-alpha

Ursolic acid, oleanolic acid

investigational

ALOX5

Arachidonate 5-lipoxygenase

Baicalin, caffeic acid, eicosatetraenoic acid

investigational

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