Figure 1
From: Ezh1 arises from Ezh2 gene duplication but its function is not required for zebrafish development
Structure of Ezh1 and its SET domain. (A) Schematic representation of the zebrafish Ezh1 protein. Red, violet and brown motifs correspond to SANT (SMART: SM00717), CXC (SMART: SM01114) and SET (SMART: SM00317) domains, respectively. The size of the protein is indicated. (B) 3D-structure of the human EZH2 SET domain (PDB ID: 4MI5) represented as a ribbon model30. The position of the substitutions identified in Ezh1 proteins are shown. Substitutions specific to ray-finned fish are in red. (C) List and nature of the substitutions identified in Ezh1 proteins are shown. Substitutions specific to ray-finned fish are in red. (D) Multiple protein alignment of the region of the SET domains between the β-sheets β1 and β5 from human (Hs) and mouse (Mm) Ezh2 and Ezh1 from several vertebrates. Hs: Homo sapiens; Mm: Mus musculus; Ss: Salmo salar; Dr: Danio rerio; Fh: Fundulus heteroclitus; Ol: Oryzia latipes; Tr: Takifugu rubripes; Xm: Xiphophorus maculatus; Nf: Nothobranchius furzeri; Mz: Maylandia zebra; Lo: Lepisosteus oculatus; Lc: Latimeria chalumnae; Rt: Rhincodon typus; Np: Nanorana parkeri; Xt: Xenopus tropicalis; Ac: Anolis carolinensis; Pv: Pagona vitticeps; Ap: Anas platyrhynchos; Mg: Meleagris gallopavo. The residues Ile650 and Cys668 are shown in blue and underlined in the EZH2 SET sequence, while Lys661 and Val662 are in red. Non-teleostean fish are indicated in green.
