Figure 2
From: Ezh1 arises from Ezh2 gene duplication but its function is not required for zebrafish development
Proposed phylogeny of vertebrates based on Ezh1-Ezh2 evolution. Proposed phylogenic tree showing changes that have occurred in Ezh1/2 SET domains during evolution. Ancient vertebrates contain only Ezh2 in their genome (Green circle). Ezh1 arose from Ezh2 gene duplication in the common ancestor to elasmobranchs and bony vertebrates (Blue circle). Additional substitutions such as the SET I650L change occurred in the common ancestor to bony vertebrates (Violet circle). Ray-finned fish including at least teleostans and holosteans harbor specific Ezh1 SET domain substitution such as K661R and V662I (Red circle). The drawings were done by Shaghayegh Hasanpour.
