Figure 6
TF contributes to S. pneumoniae virulence in vivo. BALB/c mice were inoculated intranasally with a sublethal dose (5 × 107 CFU) of the WU2 WT or WU2Δtigkan strains. Forty-eight hours following the inoculation, the mice were euthanized and their nasopharynx and lungs were excised, homogenized, and plated onto blood agar plates for enumeration. Results are a summary of three independent experiments (n = 15 in each group; Student t-test, ****p = 0.0001 and **p = 0.0031, respectively).
